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Rimeporide hydrochloride

CAS No. 187870-95-7

Rimeporide hydrochloride( EMD-87580 hydrochloride )

Catalog No. M20087 CAS No. 187870-95-7

Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rimeporide hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
  • Description
    Rimeporide (EMD-87580) is a potent and selective Sodium hydrogen exchange 1 (NHE-1) inhibitor.
  • In Vitro
    Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent.
  • In Vivo
    ——
  • Synonyms
    EMD-87580 hydrochloride
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    NHE-1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    187870-95-7
  • Formula Weight
    369.84
  • Molecular Formula
    C11H16ClN3O5S2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 18.5 mg/mL (50 mM)
  • SMILES
    Cl.Cc1cc(c(cc1C(=O)NC(N)=N)S(C)(=O)=O)S(C)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Stanbouly S et al. Sodium hydrogen exchange 1 (NHE-1) regulates connexin 43 expression in cardiomyocytes via reverse mode sodium calcium exchange and c-Jun NH2-terminal kinase-dependent pathways. J Pharmacol Exp Ther. 2008 Oct;327(1):105-13.
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